術中の血圧コントロールにおけるジルチアゼムとトリメタファンの比較検討

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  • Blood pressure control with diltiazem and trimetaphan during abdominal hysterectomy.

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One of the potent Calcium Channel Blockers: Diltiazem and a ganglion blocker: Trimetaphan were used for blood pressure control during abdominal hysterectomy. Either durg was intravenously infused when systolic blood pressure rose more than 20mmHg above preanesthesia control level or 140mmHg during surgery. Diltiazem was continuously infused for an hour at a rate of 30mg/h following initial rapid injection of 10mg, while Trimetaphan at a rate of 15mg/h following 5mg.<br>Blood pressure, heart rate, blood glucose, osmolality, electorolytes and renal function were measured prior to and following the injection of these drugs.<br>As a result, blood pressure was well controlled during surgene with either of these drugs. In Diltiazem group blood pressure was more stable, while in Trimetaphan returning of blood pressure toward injection value was often observed.<br>Decrease in heart rate and increase in urine volume were remarkable in Diltiazem. Blood sugar elevated in both groups, but hyperglycemia was less marked in Diltiazem. Therefore, it may be concluded that Diltiazem is more useful for blood pressure control during surgery comparing with Trimetaphan.

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