Effects of Low-power Laser Irradiation on the Sensory Response of Frog Cutaneous Nerves

DOI 1 Citations 40 References
  • Kogure Shinichi
    Department of Bioinformatics, Graduate School of Engineering, Soka University
  • Saito Nobuaki
    Department of Bioinformatics, Graduate School of Engineering, Soka University
  • Kozuka Kazuya
    Department of Bioinformatics, Graduate School of Engineering, Soka University
  • Tsuchiya Komei
    Department of Bioinformatics, Graduate School of Engineering, Soka University
  • Abe Takuya
    Department of Bioinformatics, Graduate School of Engineering, Soka University
  • Suzuki Yoshikazu
    Department of Bioinformatics, Graduate School of Engineering, Soka University

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  • 皮膚知覚神経応答に対する低出力レーザー照射効果

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It has been reported that low-power laser irradiation (LLI) demonstrated efficacy in treating patients with various pain syndromes and in a number of pain models. The characteristics of such effects and exact underlying mechanism, however, are still unknown. In the present study, we examined the effects of LLI on sensory responses of frog cutaneous nerve to tactile or pain stimulation to the dorsal skin surface. Fifteen frogs (Xenopus laevis) were used. They were anesthetized and immobilized by cooling, and their dorsal skins with 3-5 cutaneous nerves were prepared. Multi-unit activity from a sensory nerve bundle was recorded during the tactile or pain stimulation which was applied to its receptive field for 5 s each. Such stimulation was repeated three times before and during LLI (CW; 532 or 808 nm; 60 mW; 28.3 mm2). The multi-unit activity was discriminated every 0.2 mV based on amplitude histogram, selected with the responsiveness (larger than 5 impulses to one stimulus), and classified into 5 types (TS: tactile-specific, TD: tactile-dominant, PS: pain-specific, PD: pain-dominant, and others) according to difference of responses between tactile and pain stimulation. The number of TS, TD, PS, and PD type were 8, 26, 17 and 35, respectively. The 532 nm LLI suppressed unit responses of all 4 types and significantly decreased them from the control level (100%) before LLI to the level of 6-55% during LLI (p<0.01). The 808 nm LLI also decreased sensory responses of 4 types to the level of 23-50% (p<0.01). It is concluded that the LLI has a potential to suppress the sensory nerve responses, although such effectiveness does not show wavelength-dependency as well as stimulus-selectivity.

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