Noncontact Backscatter-Mode Near-Infrared Time-Resolved Imaging System for Functional NeuroImaging

DOI 25 References
  • Seiyama Akitoshi
    Kansai Advanced Research Center, Communications Research Laboratory Division of Physiology and Biosignaling, Osaka University Graduate School of Medicine
  • Seki Junji
    Department of Biomedical Engineering, National Cardiovascular Center Research Institute

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  • 脳活動計測に向けた非接触反射型時間分解イメージング装置の開発

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Description

While application of near-infrared spectroscopy (NIRS) to monitoring of human brain function has attracted interest of many researchers and clinicians, it has been pointed out that only low quantitative and low spatial resolution data (or topographic images) could be obtained with NIRS due to highly light scattering properties of scalp, skull, and cortex. Currently prevailing multi-channel NIRS systems consist of several sets of incident and detecting optical fiber probes. Therefore, spatial resolution of two-dimensional topographic images obtained with the multi-channel NIRS depends on the number and the distance between incident and detecting optical fibers. To improve the spatial resolution and to obtain the depth information of absorbers buried in highly scattering material, we developed a noncontact backscatter-mode near-infrared time-resolved imaging system. It consists of mode-locked Ti-sapphire lasers (780 and 830 nm at 80 MHz and 10 psec of pulse width) as light sources and a CCD camera equipped with a time-resolved intensifier as a detector. Illumination and detection of light was conducted through a large-diameter objective lens system. The system was tested with a white polyacetal phantom as a light-scattering medium and black polyacetal particles as absorbers. Spatial resolution and accuracy of absorber positions were markedly improved compared with the conventional fiber-optic topographic instruments. Here, we report a backscatter-mode near-infrared time-resolved imaging system, which has a potential to overcome the currently prevailing multi-channel NIRS systems by achieving quantitative and high-resolution imaging.

Journal

  • Nippon Laser Igakkaishi

    Nippon Laser Igakkaishi 26 (3), 222-228, 2005

    Japan Society for Laser Surgery and Medicine

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