The effect of zotepine on the excretion of purine bases
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- YAMAMOTO Tetsuya
- The Third Department of Internal Medicine, Hyogo College of Medicine
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- MAEDA Juichiro
- The Third Department of Internal Medicine, Hyogo College of Medicine
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- MORIWAKI Yuji
- The Third Department of Internal Medicine, Hyogo College of Medicine
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- TAMURA Shinsuke
- The Third Department of Internal Medicine, Hyogo College of Medicine
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- HADA Toshikazu
- The Third Department of Internal Medicine, Hyogo College of Medicine
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- HIGASHINO Kazuya
- The Third Department of Internal Medicine, Hyogo College of Medicine
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- OGAWA Kenji
- The Neuropsychiatric Department, Ninmonkai Hospital
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- YANAGIZAWA Masahiro
- The Neuropsychiatric Department, Ninmonkai Hospital
Bibliographic Information
- Other Title
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- 抗精神病薬zotepineのプリン塩基排泄に対する影響
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Abstract
We investigated the effect of zotepine on uric acid, xanthine and hypoxanthine in patients with schizophrenia. In addition, we performed pyrazinamide - suppression test and phenolsulfophthale in test to identify the site of its uricosuric action in the kidney.<BR>Zotepine had a hypouricemic effect in patients with schizophrenia as reported previously, although the effect was not dose-dependent. In 6 patients treated with zotepine (40 mg/day), the serum uric acid value rose quickly one week after discontinuation of zotepine and returned close to the pretreatment level after two weeks.<BR>Pyrazinamide blocked the uricosuric action of zotepine to the same degree as it did the uricosuric action of benzbromarone but phenolsulfophthale in excretion was not inhibited by zotepine as by benzbromarone. These findings indicate that zotepine exerts its uricosuric action at postsecretory sites. Zotepine increased the xanthine clearance/creatinine clearance ratio significantly. but decreased the hypoxanthine clearance /creatinine clearance ratio significantly. These results suggest that the renal transport mechanisms of uric acid and xanthine are similar to each other but are different from that of hypoxanthine.
Journal
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- Uric acid research
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Uric acid research 9 (1), 61-68, 1985
Japanese Society of Gout and Nucleic Acid Metabolism
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Details 詳細情報について
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- CRID
- 1390001204767239424
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- NII Article ID
- 130003354903
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- ISSN
- 21870098
- 03884120
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed