Chemical and Biological Properties of ICG-Lipo

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  • Suganami Akiko
    Department Bioinformatics, Graduate School of Medicine, Chiba University
  • Toyota Taro
    Department Bioinformatics, Graduate School of Medicine, Chiba University Department of Basic Science, Graduate School of Arts and Sciences, The University of Tokyo
  • Okazaki Shigetoshi
    Medical Photonics Research Center, Hamamatsu University School of Medicine
  • Hayashi Hideki
    Center for Frontier Medical Engineering
  • Okamoto Yoshiharu
    Department of Veterinary Clinical Medicine, Faculty of Agriculture, Tottori University
  • Tamura Yutaka
    Department Bioinformatics, Graduate School of Medicine, Chiba University

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  • ICG-Lipo の化学的・生物学的特性

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We have designed and synthesized a novel near-infrared (NIR) photoactivating probe, designated by ICG-Lipo, in which an indocyanine green (ICG) fluorophore is covalently tagged with alkyl chains or a phospholipid moiety to incorporate into liposome bilayers. Our results indicate that ICG-Lipo is a useful NIR-fluorescence probe for noninvasive in vivo bioimaging, especially for the sentinel lymph node and for photodynamic thermal therapy.

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