大腸菌内毒素による正円窓膜病変の電顕的観察

DOI

書誌事項

タイトル別名
  • Pathological change of the round window membrane induced by endotoxin from escherichia coli.

抄録

Pathologic change of the round window membrane (RWM) in guinea pigs induced by the endotoxin from E. coli were observed by the electron microscopy and the effect of the endotoxin on the permeability of the RWM was examined by a tracer using horseradish perioxidase (HRP).<BR>Twenty four hours after injection of the endotoxin (Sigma, 100 μg/ml) into the bulla, RWM invariably demonstrated inflammatory changes remniscent to those of middle ear effusion: The subepithelial space was characterized by marked edema, where a large number of neutrophils and red blood cells and a few mononuclear cells appeared. These infiltrating cells were seen often migrating in scala tympani but no definite damages to the organ of Corti present.<BR>When exposed to HRP, these pathologic RWM demonstrated normal uptake of the tracer into the epithelial cells as well as into some of the fibrous cells of the middle layer. However, we could not confirm increase of permeability of RWM, as evaluated by the amount of intracellular uptake of the tracer.

収録刊行物

詳細情報 詳細情報について

  • CRID
    1390001204769073408
  • NII論文ID
    130004355936
  • DOI
    10.11289/otoljpn1981.20.3
  • ISSN
    18845797
    02889781
  • 本文言語コード
    ja
  • データソース種別
    • JaLC
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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