Immunoglobulin therapy for otitis-prone children.

DOI 2 Citations 11 References

Bibliographic Information

Other Title
  • 免疫グロブリン製剤による乳幼児反復性中耳炎の治療

Search this article

Description

The present investigation was undertaken in order to evaluate the effectiveness of intravenous injection of immunoglobulin (IVIG) treatment for the otitis-prone children under 2 years old without evident immunodeficiency. Twenty children suffered from at least 5 or more episodes of acute otitis media during the past 6 month-follow-up period were designated as the otitis-prone group, ere subjected to the present study. The otitis-prone children were given 2 to 5 injections of IVIGs (2.5g of Venoglobulin IH®) until they became 24 to 30 months. The serum level of IgG2 and specific antibody to S. pneumonia, the incidence of acute otitis media and tympanogram before and after the treatment were periodically investigated.<BR>Before IVIG treatment, total episodes of acute otitis media of the 20 otitis-prone children were 162 times during the total periods of 147 months. After IVIG treatment, the episodes dramatically decreased to 11 times for 162 months. The mean serum level of antibody against S. pneumonia was 1.7μg/ml in otitis-prone group, which was statistically significantly lower than that of the healthy control group of 3.4μg/ml (p=0.002). The serum antibody levels significantly increased up to those of control group after the IVIG treatment.<BR>In 14 ears tympanometry showed alternatively type A and B, and in 24 ears it showed persistently type B before IVIG treatment. After IVIG treatment tympanogram normalized in all ears of alternate A between B type group and 15 ears of persistent B type group. The shorter the duration from the initial episode of acute otitis media to the first IVIG treatment, the higher the rate of normalization of tympanogram (x2 test, p=0.016). These results showed that IVIG treatment is very effective for severe recurrent acute otitis media under 2 years of age.

Journal

  • Otology Japan

    Otology Japan 5 (2), 132-137, 1995

    Japan Otological Society

Citations (2)*help

See more

References(11)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top