正円窓膜の内耳蝸牛に対する役割 (IV)

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タイトル別名
  • Effect of the Round Window Membrane to Inner Ear

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説明

After the closure of the round window membrane of guinea pig by various adhesive agents, the inner ear function were observed by cochlear microphonics (CM) and action pctential (AP). At the same time, the perilymphatic oxygen tension in scala tympani were measured by polarographic methods.<BR>CM and AP were significantly dropped after three weeks of closure and the perilymphatic oxygen tension of closed side dropped about 50% compared with non-closed side.<BR>In addition to these chronic experiment, dynamic changes of the perilymphatic oxygen tension were measured after flowing air, pure oxygen and nitrogen.<BR>As a result, the perilymphatic oxygen tension significantly increased after flowing pure oxygen, but decreased after flowing nitrogen.<BR>We assumed that these results were caused by some disturbance of oxygen transport from the middle ear cavity to perilymphatic space through the round window membrane.

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