バナジウム化合物の蝸牛内静止電位への影響

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  • Effect of Vanadium Compounds on Endocochlear Potential

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説明

It is generally considered that Na+, K+-ATPase participates to generate the Endocochlear DC Potential (EP) in the stria vascularis. In 1983, we reported the inhibitory effect of Vanadate (Na3VO4) on this enzyme. Vanadium which is a transition metal element has several oxidation states such as +3, +4, +5. The present study was to define electrophysiologically which forms of vanadium were effective on EP and CM. With perilymphatic perfusion of Vanadate (Na3VO4, NHVO3, KVO3: +5) at the concentration of 1mM, EP was increased for a few minutes at the beginning, following of gradual reductions of EP and CM in thirty minutes. Whereas, no changes in EP and CM by perfusion with others oxidation number of Vanadium (VOSO4: +4, VCl3, V (C5H7O2) 3: +3). Even after the perfusion for thirty minutes, a large magnitude of negative EP was observed in every case when anoxia have enforced. From the results obtained that the generation of EP is inhibited by vanadium compounds the +5 oxidation state.

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