Evidence-based medicine. How to treat the patients with Meniere's disease.

DOI 1 Citations 17 References
  • Takeda Noriaki
    Department of Otolaryngology, University of Tokushima School of Medicine

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  • メニエール病の治療におけるＥＢＭ

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Abstract

For the treatment of patients with Meniere's disease in the acute period, randomized controlled trials showed that anti-vertigo drugs, such as diphenidol and betahistine, are significantly effective. In the chronic period, Meniere's disease is specifically managed by osmotic diuretic, isosorbide. The dose comparative study showed that its opitimal dose is 90ml/day. Despite many controversies against endolymphatic sac surgery, including the Danish sham surgery study suggesting a placebo effect of mastoidectomy, the efficacy of the procedure is widely accepted. However, it is not clear that endolymphatic sac surgery alters the natural history of Meniere's disease in a long term.

Journal

  • Otology Japan

    Otology Japan 10 (3), 147-149, 2000

    Japan Otological Society

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