Hair cell regeneration after kanamycin ototoxicity in the chick cochlea.

DOI
  • Hashino Eri
    Department of Otolaryngology, Dokkyo University School of Medicine Koshigaya Hospital
  • Tanaka Yasuo
    Department of Otolaryngology, Dokkyo University School of Medicine Koshigaya Hospital

Bibliographic Information

Other Title
  • カナマイシン中毒後におけるヒヨコ聴器有毛細胞の再生

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Description

Kanamycin was injected to three-day-old chicks at a dose of 200mg/kg. for 10 days and their cochleae were processed for scanning electron microscopy at various times following the last injection. Both hair cells and supporting cells were damaged by kanamycin in the basal 35-40% of the basilar papilla. By 14 days posttreatment, most of the damaged region was replaced with regenerating hair cells and supporting cells. The base-to-apex gradient of morphological development along the longitudinal axis of the cochlea was observed in the course of regeneration. Kinocilium and microvilli were recognized on the apical surface of the regenerating hair cells.

Journal

  • Ear Research Japan

    Ear Research Japan 21 (1), 335-336, 1990

    THE JAPAN OTOLOGICAL SOCIETY

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