ポリアミノ化合物の聴器毒性に関する研究 (第1報)

DOI

書誌事項

タイトル別名
  • Ototoxicity of Polyamino-compounds (Report I)
  • A Study by Perilymphatic Perfusion
  • 外リンパ腔灌流法による検討

説明

The ototoxicity of polyamino-compounds was exmined by means of perilymphatic perfusion, while monitoring cochlear microphonics (CM) as an indicator of ototoxicity. The selected polyamino-compounds were kanamycin, polymyxin B, poly-L-lysine, putrescine, and spermine; 10mM of each compound was perfused through the perilymphatic space, and ototoxicity was determined.<BR>Polymyxin B and poly-L-lysine caused the disappearance of cochlear microphonic potentials (CM) within 15 min after the start of perfusion. Both putrescine and spermine caused moderate depression of CM, however; it was not so severe as that caused by kanamycin.<BR>It was suggested that the ototoxicity of polymyxin B and poly-L-lysine was caused by their binding to the polyphosphoinositide receptor in much the same way kanamycin did. But the ototoxicities of putrescine and spermine did not seem to be concerned with polyphosphoinositide.<BR>Further study is necessary to understand the mechanism of the ototoxicity of polyamino-compounds.

収録刊行物

詳細情報 詳細情報について

  • CRID
    1390001204771105280
  • NII論文ID
    130004354989
  • DOI
    10.11289/otoljpn1981.13.100
  • ISSN
    18845797
    02889781
  • データソース種別
    • JaLC
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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