Closing Tympanic Membrane Perforations by Autologous Serum Eardrops Therapy with a Chitin Membrane and a Collagen Sponge

DOI
  • Sasaki Akira
    Department of Otorhinolaryngology, Hirosaki University Graduate School of Medicine, Hirosaki University Graduate School of Medicine
  • Kakehata Seiji
    Department of Otolaryngology Head and Neck Surgery, Yamagata University Faculty of Medicine
  • Hirose Yuki
    Department of Otolaryngology, Graduate School of Comprehensive Human sciences, University of Tsukuba
  • Takeda Ikuko
    Department of Otorhinolaryngology, Hirosaki University Graduate School of Medicine, Hirosaki University Graduate School of Medicine
  • Matsubara Atsushi
    Department of Otorhinolaryngology, Hirosaki University Graduate School of Medicine, Hirosaki University Graduate School of Medicine
  • Shinkawa Hideichi
    Department of Otorhinolaryngology, South Miyagi Medical Center

Bibliographic Information

Other Title
  • キチン膜およびコラーゲンスポンジを用いた自己血清点耳療法による鼓膜穿孔閉鎖術

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Description

Recently, various alternative outpatient treatments to the conventional myringoplasty without autografts have been reported for closing tympanic membrane perforations. In our outpatient clinic, we have performed autologous serum eardrops therapy (ASET) in 55 ears (20 males, 35 females) in 53 patients aged 6-86 years (mean, 49.0 years) with perforation. The perforation margin was cauterized with silver nitrate, and the perforation was covered with a chitin membrane. Patients were instructed to apply autologous serum eardrops daily at home. In the patients with perforations not closed by this procedure, we inserted collagen sponges, and then patients applied autologous serum eardrops again.<br>The overall closure rate before insertion of collagen sponges was 61.8%. Regarding possible factors related to the closure rate, we evaluated patients' ages, perforation size, duration from onset to treatment, allergic rhinitis, infections and other complications. But none of these were significantly correlated to the closure rate. In the cases required collagen sponges, the closure rate after insertion was 72.7%, and the final overall closure rate was 76.4%.<br>ASET was very easy and safe and will be a feasible method for closing tympanic membrane perforations in a variety of clinical settings.

Journal

  • Otology Japan

    Otology Japan 24 (3), 200-208, 2014

    Japan Otological Society

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