Loss of Isosorbide Dinitrate or Nitoglycerin Solution Content in Practice Injection of Precision Continuous Drip Infusion.

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  • 精密持続点滴中の硝酸イソソルビドあるいはニトログリセリン注射液の含量低下

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We investigated the effect of drip conditions on the loss of isosorbide dinitrate (ISDN) or nitroglycerin (GTN) solution contens in practice injection of precision continuous drip infusion. When ISDN or GTN solutions for injection were passed through an intravenous administration tube 100cm in length and 2.1mm inside diameter, at a flow rate of 5.0ml/h, the ISDN or GTN concentrations were reduced to about 30.6% or 10.8% in 60 minutes respectively, and gradually returned to the initial level with time.<BR>It was found that the factors affecting the percentage of remaining ISDN were the length and the inside diameter of the administration tube, the drip rate of the solution, and the tube materials used. Moreover, it was suggested that the amount of ISDN remaining after passage through the administration tube was closely related with the time in which the administration tube was used.

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