Factors Associated with Neurotoxicity in Patients Receiving FOLFOX 4
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- Imai Toru
- Department of pharmacy, Nihon University Itabashi Hospital
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- Hayasaka Masatoshi
- Department of pharmacy, Nihon University Itabashi Hospital
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- Chuma Masayuki
- Department of pharmacy, Nihon University Itabashi Hospital
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- Koinuma Masayoshi
- College of Pharmacy, Nihon University
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- Hayama Tatsuya
- Department of pharmacy, Nihon University Itabashi Hospital
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- Nakayama Toshimitsu
- Department of pharmacy, Nihon University Itabashi Hospital
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- Yoshida Yoshikazu
- Department of pharmacy, Nihon University Itabashi Hospital
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- Tanjoh Katsuhisa
- Department of pharmacy, Nihon University Itabashi Hospital
Bibliographic Information
- Other Title
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- FOLFOX 4 療法における末梢神経障害発症に関与する臨床的因子の検討
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Abstract
Oxaliplatin (L-OHP) in combination with infusional 5-fluorouracil/leucovorin (FOLFOX) has been established as a core therapy for advanced and recurrent colorectal cancer.In this case,sensory neurotoxicity is its dose-limiting toxicity.We evaluated it using the Neurotoxicity Criteria of DEBIOPHARM and conducted a retrospective analysis to determine sensory neurotoxicity-associated clinical factors.<br>Seventy patients with advanced recurrent colorectal cancer who received FOLFOX 4 therapy from November 2005 to February 2008 were the subjects of the present study.The median number of courses until expression of grade 1 neurotoxicity was six (range 1~17 courses) and that for grade 2 neurotoxicity was ten (range 3~18 courses).<br>A logistic regression analysis performed to determine patient background and laboratory data that affect the incidence of sensory neurotoxicity revealed that risk factors involving sensory neurotoxicity were WBC(×~103/μL)[odds ration: 0.7556 (95% confidence interval:0.6740-0.8471)],Amylase (Logarithm natural)[1.7766:(1.0879-2.9011)],Transition [1.7850:(1.1647-2.7354)]and L-OHP cumulative dose (g)[2.2399:(1.5810-3.1734)].<br>These findings suggest that pharmacists should carefully monitor the rational symptoms in patients undergoing FOLFOX for advanced and recurrent colorectal cancer,particularly in those with risk factors for sensory neurotoxicity.
Journal
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- Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)
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Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences) 36 (5), 347-351, 2010
Japanese Society of Pharmaceutical Health Care and Sciences
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Details 詳細情報について
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- CRID
- 1390001204775112960
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- NII Article ID
- 130004502604
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- ISSN
- 18821499
- 1346342X
- http://id.crossref.org/issn/1346342X
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed