Autoimmune Hemolytic Anemia and Other Adverse Reactions to α-Methyldopa

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  • OZAKI Susumu
    Division of Pharmacy, Sappro Hospital, Hokkaido Association of Medical Service for Workers
  • YOSHIOKA MITSUGU
    Division of Pharmacy, Sappro Hospital, Hokkaido Association of Medical Service for Workers

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Other Title
  • α-メチルドパによる自己免疫性溶血性貧血, およびその他の副作用調査

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It has been known that 10-20 % of patients on α-methyldopa therapy become positive to Coombs' test and some of them develop autoimmune hemolytic anemia. In Japan these cases are rarely reported (only 5 of 1, 064 patients treated with α-methyldopa). Adverse reactions to α-methyldopa in 93 outpatients were studied. None of the patients showed positive Coombs' test and clinical signs of hemolytic anemia, but other adverse reactions occurred in some patients.

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