Involvement of Allergic Reactions in Skin Eruption Induced by S-1

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  • S-1 による薬剤性皮膚障害でのアレルギー反応の関与

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S-1 (tegafur-gimeracil-oteracil potassium combination) is a biochemical modulating agent which enhances anti-cancer efficacy and reduces the toxicity of 5-FU with respect to the digestive tract.We collected data on its adverse effects at Fukuoka University Hospital for evaluation and analysis,using the leukocyte migration test (LMT) for evaluation of adverse effects.We report the results of the evaluation for patients with skin eruption caused by S-1.<br>After extracting mononuclear cells from heparinized peripheral blood taken from the patients,we mixed them with 3 drugs (S-1,5-FU,UFT capsule 100 mg® (UFT)) and incubated for 72 hours.We then collected the supernatant fluid and conducted the LMT using granulated leukocytes from healthy subjects in a 96-well chemotaxis chamber.In a period of 1 year,we encountered 5 patients with skin eruption associated with S-1 and evaluated 2 of them by the LMT.The results for 5-FU,S-1,and UFT were negative,positive,and positive,respectively,suggesting that tegafur,the common component of S-1 and UFT,was the cause of the allergic reaction and skin eruption.

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