Stability of Copper Histidinate Injection and Histamine Formation in Menkes Disease
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- Kawasaki Yoichi
- Department of Hospital Pharmacy, Okayama University Medical and Dental School
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- Tokunaga Shin
- Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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- Matsuka Naoyuki
- Department of Hospital Pharmacy, Okayama University Medical and Dental School
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- Izushi Michihiro
- Department of Hospital Pharmacy, Okayama University Medical and Dental School
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- Yokoyama Noriko
- Department of Hospital Pharmacy, Okayama University Medical and Dental School
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- Kawashima Rieko
- Department of Hospital Pharmacy, Okayama University Medical and Dental School
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- Kamei Chiaki
- Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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- Sendo Toshiaki
- Department of Hospital Pharmacy, Okayama University Medical and Dental School
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- Gomita Yutaka
- Department of Hospital Pharmacy, Okayama University Medical and Dental School
Bibliographic Information
- Other Title
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- ヒスチジン銅注射液の安定性およびヒスタミン含有量の検討
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Description
Menkes disease is characterized by inhibition of the absorption and transport of dietary copper. The Okayama University Medical and Dental School uses L-histidine-copper to treat this disease and in the present study, we examined the stability of the copper histidinate injection solution used for this purpose. High-performance liquid chromatography (HPLC) performed on day 56 following injection revealed that histidine levels had dropped to 90.4%, a non-significant decrease and histamine levels were unchanged. Moreover, atomic absorption spectrophotometry revealed that copper concentrations were not significantly decreased (89.7%) between days 0 and 56. Through visual observation, we noted a gradual increase in floats from day 42 to day 56, leading us to suggest that the use of copper histidinate be limited to 1 month.<br>The above results should alleviate any concern about histamine-associated adverse effects.
Journal
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- Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)
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Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences) 32 (11), 1133-1137, 2006
Japanese Society of Pharmaceutical Health Care and Sciences
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Details 詳細情報について
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- CRID
- 1390001204775939840
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- NII Article ID
- 110005518961
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- NII Book ID
- AA11527197
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- ISSN
- 18821499
- 1346342X
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- NDL Digital Collections (NII-ELS)
- CiNii Articles
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- Abstract License Flag
- Disallowed
