No Change in Serum Concentrations of Amiodarone and Desethyl-amiodarone in Vicinity of Cardiopulmonary Bypass Surgery : A case report
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- Nakakura Ichiro
- Department of Pharmacy, National Cerebral and Cardiovascular Center
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- Yamashita Daisuke
- Department of Pharmacy, National Cerebral and Cardiovascular Center
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- Kohrai Mutsuko
- Department of Pharmacy, National Cerebral and Cardiovascular Center
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- Horibe Akemi
- Department of Pharmacy, National Cerebral and Cardiovascular Center
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- Wada Kyoichi
- Department of Pharmacy, National Cerebral and Cardiovascular Center
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- Kohara Nobuaki
- Department of Pharmacy, National Cerebral and Cardiovascular Center
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- Shimahara Yusuke
- Department of Cardiovascular Surgery, National Cerebral and Cardiovascular Center
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- Kobayashi Junjiro
- Department of Cardiovascular Surgery, National Cerebral and Cardiovascular Center
Bibliographic Information
- Other Title
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- 体外循環施行前後ではアミオダロンおよびアミオダロン代謝物の血中濃度変化は認められない ～ 1症例報告 ～
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Abstract
It has been reported that cardiopulmonary bypass (CPB) surgery influences the pharmacokinetics of various drugs. In this study, we investigated serum concentrations of amiodarone (AMD) and desethyl-amiodarone (DEA), the amiodarone metabolite, in the vicinity of CPB. Our patient was taking amiodarone tablets because other antiarrhythmic agents had been ineffective against premature ventricular contraction and nonsustained ventricular tachycardia. The patient underwent aortic valve replacement under CPB for aortic stenosis, and serum concentrations of AMD and DEA were measured in the vicinity of the CPB surgery before and after it. There was no change in the serum concentrations (before CPB surgery; AMD : 0.71 μg/mL, DEA : 0.47 μg/mL, after CPB surgery; AMD : 0.85 μg/mL, DEA : 0.46 μg/mL). During and after surgery, no atrial or ventricular tachyarrhythmia was observed.<br>We considered that serum concentrations of AMD and DEA were not influenced by CPB because of amiodarone's high protein binding ratio and large distribution volume, which are characteristics of this drug.
Journal
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- Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)
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Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences) 37 (12), 707-711, 2011
Japanese Society of Pharmaceutical Health Care and Sciences
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Details 詳細情報について
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- CRID
- 1390001204776880128
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- NII Article ID
- 130004894769
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- ISSN
- 18821499
- 1346342X
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed