Effect of TDM on Frequency of Digoxin Toxicity.

DOI NDL Digital Collections 4 Citations 9 References
  • UENO KAZUYUKI
    Department of Pharmacy, National Sanatorium Sengokuso Hospital
  • UCHIMI YORIKO
    Department of Pharmacy, National Sanatorium Sengokuso Hospital
  • ISHIDA YASUHARU
    Internal Medicine, National Sanatorium Sengokuso Hospital
  • 川口 義廣
    国立療養所千石荘病院内科
  • YAMAGUCHI RIYO
    Respiratory Disease, National Sanatorium Sengokuso Hospital
  • KATO MOTOICHI
    Respiratory Disease, National Sanatorium Sengokuso Hospital
  • ARIMOTO JUNJI
    Surgery, Internal Medicine, Vice-President, National Sanatorium Sengokuso Hospital
  • SUZUKI YOSHIO
    Surgery, Internal Medicine, Vice-President, National Sanatorium Sengokuso Hospital
  • KOYAMA MICHIKO
    Surgery, Internal Medicine, Vice-President, National Sanatorium Sengokuso Hospital
  • BITO KEIZO
    Internal Medicine, National Sanatorium Sengokuso Hospital
  • KONISHI TOMOTSUGU
    Respiratory Disease, National Sanatorium Sengokuso Hospital

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Other Title
  • ジゴキシンの副作用発現頻度に及ぼすＴＤＭの寄与

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Therapeutic drug monitoring (TDM) was instituted as a routine task in our hospital from 1985. Examination of the frequency of digoxin toxicity was conducted during the 9-year period from 1985 to 1993. Though the frequency was about 8% in 1985 and 1896, however, it gradually decreased every year to the level of about 1% for the last two years. This suggests that TDM is an effective measure for decreasing the frequency of digoxin toxicity.

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