Stability of Vitamin B1, and C in New Total Parenteral Nutrition Kit Products in Presence of Trace Elements

DOI 2 Citations 3 References
  • Matsubara Hajime
    Department of Pharmacy, Kitasato University Hospital
  • Otori Katsuya
    School of Pharmacy, Kitasato University
  • Toyoda Taichi
    Information Center for Infusion Therapy and Product, Otsuka Pharmaceutical Factory, Inc.
  • Kaga Junji
    Information Center for Infusion Therapy and Product, Otsuka Pharmaceutical Factory, Inc.
  • Yago Kazuo
    Department of Pharmacy, Kitasato University Hospital School of Pharmacy, Kitasato University

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  • 新規ＴＰＮキット製剤の微量元素存在下でのビタミンＢ１，Ｃの安定性

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In many cases in the clinical setting,trace elements are mixed with TPN products.However,in such therapy the rapid oxidative decomposition of vitamin C is a problem.In view of this,we investigated the stability of vitamin C in a newly developed kit product for TPN (ELNEOPA No.1 and No.2 Injections) which contains trace elements in addition to glucose,electrolytes,amino acids,and vitamins.<br>We evaluated the stability of vitamin C after mixing all the ingredients of ELNEOPA in comparison with the control solution (admixture of commercial TPN solution containing vitamins and a trace element preparation).Though vitamin C rapidly decomposed in the control solution,it was stable in ELNEOPA,with not less than 90% of the labeled amount remaining 7 days after mixing.The container (plastic bag) of ELNEOPA is made from a high gas barrier film and we consider the stability of vitamin C in it to be due to the film preventing an increase in oxygen in the solution.Also,as at least 90% of the labeled amount of vitamin B1 was still present 7 days after mixing,ELNEOPA is considered to be a very useful preparation for TPN therapy,including that in the home.

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