抗菌薬,抗がん剤による薬物療法における乳酸菌生菌製剤の併用状況

書誌事項

タイトル別名
  • Investigation Concerning Combined Use of Acidophilus Biologics and Antibiotics or Anticancer Drugs

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説明

Diarrhea is a very common,important adverse effect associated with antibiotic therapy.For the prevention and treatment of diarrhea,Biofermin (BF) probiotic preparations are prescribed frequently and an antibiotic-resistant probiotic BioferminR (BFR) is particularly useful against antibiotic-associated diarrhea.BFR is often prescribed in combination with antibiotics to which the probiotic is susceptible or with off-label drugs such as anti-cancer drugs.<br>We investigated the concurrent usage of such probiotics and antibiotics and anti-cancer drugs using data from the database of a computer order entry system at the Tokushima University Hospital (April 2006 to March 2008),as well through the use of a questionnaire given to hospital doctors.The results of our study suggested that not all doctors had a sufficient knowledge of the usage of BFR when prescribing it.In routine pharmacy work,pharmacists should therefore actively question doctors concerning prescriptions they have written for the combination of BFR and off-label drugs to ensure the proper use of BFR and prevent the emergence of drug-resistant bacteria due to bacterial mutagenicity associated with antibiotics and anti-cancer drugs.

収録刊行物

  • 医療薬学

    医療薬学 35 (5), 360-367, 2009

    一般社団法人日本医療薬学会

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