<I>Effect of an immunomodulator, ‘lobenzarit disodium’ (CCA), on various experimental models of inflammation</I>

DOI

Bibliographic Information

Other Title
  • 種々の炎症反応モデルに及ぼす免疫調節剤lobenzarit disodium (CCA) の影響

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Description

Lobenzarit disodium (CCA; disodium 4-chloro-2, 2'-iminodibenzoate) had no inhibitory effect on carrageenan eodema, cotton pellet granulomatosis, acetic acid writhing test, hot plate test and passive cutaneous anaphylaxis reaction. CCA also did not show an inhibitionin vitroPGE2biosynthesis. These results clearly show that CCA is quite different from mefenamic acid in its biological activities while the chemical structures of both are similar. The suppressive and inhibitory effects of CCA on the immunologically-induced murine inflammation such as adjuvant arthritis and methylated bovine serum albumin-induced arthritis in rats or spontaneously occurred autoimmune diseases in NZB/NZW F1and MRL/1 mice, were thought to be derived from its immunomodulating activity.

Journal

  • Ensho

    Ensho 4 (3), 239-242, 1984

    The Japanese Society of Inflammation and Regeneration

Details 詳細情報について

  • CRID
    1390001204783980544
  • NII Article ID
    130003856734
  • DOI
    10.2492/jsir1981.4.3_239
  • ISSN
    18844006
    03894290
  • Data Source
    • JaLC
    • Crossref
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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