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<I>Effect of an immunomodulator, ‘lobenzarit disodium’ (CCA), on various experimental models of inflammation</I>
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- Tanemura Mitsuru
- Research Laboratories, Chugai Pharmaceutical Co., Ltd.
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- Nakano Toshiaki
- Research Laboratories, Chugai Pharmaceutical Co., Ltd.
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- Ohsugi Yoshiyuki
- Research Laboratories, Chugai Pharmaceutical Co., Ltd.
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- Ikeda Yugo
- Research Laboratories, Chugai Pharmaceutical Co., Ltd.
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- Hata Shun-ichi
- Research Laboratories, Chugai Pharmaceutical Co., Ltd.
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- Takagaki Yoshio
- Research Laboratories, Chugai Pharmaceutical Co., Ltd.
Bibliographic Information
- Other Title
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- 種々の炎症反応モデルに及ぼす免疫調節剤lobenzarit disodium (CCA) の影響
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Description
Lobenzarit disodium (CCA; disodium 4-chloro-2, 2'-iminodibenzoate) had no inhibitory effect on carrageenan eodema, cotton pellet granulomatosis, acetic acid writhing test, hot plate test and passive cutaneous anaphylaxis reaction. CCA also did not show an inhibitionin vitroPGE2biosynthesis. These results clearly show that CCA is quite different from mefenamic acid in its biological activities while the chemical structures of both are similar. The suppressive and inhibitory effects of CCA on the immunologically-induced murine inflammation such as adjuvant arthritis and methylated bovine serum albumin-induced arthritis in rats or spontaneously occurred autoimmune diseases in NZB/NZW F1and MRL/1 mice, were thought to be derived from its immunomodulating activity.
Journal
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- Ensho
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Ensho 4 (3), 239-242, 1984
The Japanese Society of Inflammation and Regeneration
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Details 詳細情報について
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- CRID
- 1390001204783980544
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- NII Article ID
- 130003856734
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- ISSN
- 18844006
- 03894290
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed