書誌事項
- タイトル別名
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- Influenes of lipid fractionation in iodine-enriched egg on histamine and LT-C4 release by antigen challenged lung fragments and arachidonate metabolism enzyme in leukocytes.
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抄録
The authors investigated anti-allergic and anti-inflammatory mechanisms in iodine enriched eggs. Both total and neutral lipid fractionation in iodine enriched eggs suppressed the histamine release in response to an antigen challenge of passively immunized lung mast cells in a dose dependent manner. LT-C4 production in antigen challenged atopic leukocytes was also suppressed by both total and neutral lipid fractionation. The suppressive mechanisms of iodine enriched eggs were investigated using leukocyte lysate as enzyme preparations of 5-lipoxygenase system. Neutral lipid fractionation did not inhibit LT-B4 production, ie., 5-lipoxygenase activity, but did inhibit LT C4 production, i.e., LT-C4 synthase activity. Polar lipid fractionation inhibited neither LTB4 production nor LT-C4. These results suggested that neutral lipid fractionation of iodine enriched eggs modulated histamine release in lung mast cells and LT-C4 production in leukocytes with antigen provocation. Furthermore, it was possible for neutral lipid fractionation to inhibit LT C4 synthase activity in leukocytes.
収録刊行物
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- 炎症
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炎症 18 (1), 19-23, 1998
日本炎症・再生医学会
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キーワード
詳細情報 詳細情報について
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- CRID
- 1390001204784053888
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- NII論文ID
- 130003709529
- 10009358815
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- NII書誌ID
- AN00357213
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- ISSN
- 18844006
- 03894290
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可