Changes of brain cholecystokinin levels in dogs with Eck fistula and DMN-induced acute hepatic failure: special reference to the ammonia and aromatic amino acid levels in blood and cerebrospinal fluid.

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  • MIURA Yoshiaki
    The First Department of Internal Medicine, Iwate Medical University

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  • Ｅｃｋろう犬およびＤＭＮ急性肝不全犬における脳ｃｈｏｌｅｃｙｓｔｏｋｉｎｉｎの変動とくに血液および髄液のアンモニアと芳香族アミノ酸との関連

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Cholecystokinin-8 like immunoreactivity (CCK-8 IR) was measured in brains of Eck fistula and DMN (dimetylnitrosamine)-induced acute hepatic failure dogs which were prepared as experimental models of hepatic encephalopathy, and studies were conducted to investigate correlations among brain CCK-8 IR, ammonia and aromatic amino acid levels in blood and cerebrospinal fluid.<BR>Significant reductions of CCK-8 IR levels were observed not only in all areas of cerebral cortex, thalamus and midbrain of Eck fistula dogs, but also in parietal lobe, temporal lobe and thalamus of DMN-induced acute hepatic failure dogs.<BR>There was a tendency of correlation between reduced brain CCK-8 IR levels and increased ammonia levels in blood and cerebrospinal fluid, but not a tendency of correlation between reduced brain CCK-8 IR levels and increased aromatic amino acid levels in blood and cerebrospinal fluid.<BR>These results suggest that reduced CCK-8 IR levels in brains of dogs with hepatic encephalopathy are concerned with increased ammonia levels in blood and cerebrospinal fluid.

Journal

  • Kanzo

    Kanzo 32 (4), 403-410, 1991

    The Japan Society of Hepatology

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