A case of steroid-resistant autoimmune hepatitis effectively treated with cyclosporine

DOI Web Site Web Site 3 Citations 8 References
  • KIM Minil
    Second Department of Internal Medicine, Showa University School of Medicine Division of Internal Medicine, Fujiyoshida Municipal Hospital
  • ITO Takayoshi
    Second Department of Internal Medicine, Showa University School of Medicine
  • MIKI Hiroyuki
    Second Department of Internal Medicine, Showa University School of Medicine Division of Internal Medicine, Fujiyoshida Municipal Hospital
  • TAKAHASHI Seiichirou
    Division of Internal Medicine, Fujiyoshida Municipal Hospital
  • NAKANO Masayuki
    National Hospital Organization Chiba Medical Center
  • IMAWARI Michio
    Second Department of Internal Medicine, Showa University School of Medicine

Bibliographic Information

Other Title
  • ステロイド治療に抵抗しシクロスポリン併用にて寛解維持を得た自己免疫性肝炎の１例
  • 症例報告 ステロイド治療に抵抗しシクロスポリン併用にて寛解維持を得た自己免疫性肝炎の1例
  • ショウレイ ホウコク ステロイド チリョウ ニ テイコウ シ シクロスポリン ヘイヨウ ニテ カンカイイジ オ エタ ジコ メンエキセイ カンエン ノ 1レイ

Search this article

Description

Fifty years old female was admitted due to acute liver injury and diagnosed as having autoimmune hepatitis. She was treated with a high dose of metyhlprednisolone, and recovered from the liver injury. Reduction of steroid led to recurrence of liver injury. Since addition of azathioprine was not effective, we treated her with a high dose of steroid again. During tapering of steroid in the presence of azathioprine, she relapsed again. Because of the use of a large total amount of steroid and difficulty of tapering steroid, we replaced azathioprine with cyclosporine A. After the alteration, she has remained in remission with decreasing amount of steroid. About 10% of patients with autoimmune hepatitis are resistant to the steroid therapy, and there are some responders who cannot continue it due to its adverse effects. Combination therapy with cyclosporine A and a minimal amount of steroid may be useful for such patients.

Journal

  • Kanzo

    Kanzo 46 (7), 406-413, 2005

    The Japan Society of Hepatology

Citations (3)*help

See more

References(8)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top