新しく発見された肝細胞質内封入体“リング体”　　その出現の意義

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  • A newly recognized hepatic inclusion body, "ring body". Significance of its occurence.
  • significance of its occurence
  • その出現の意義

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Recently, we discovered new intracytoplasmic inclusion bodies in hepatocytes, Kupffer cells and macrophages. The bodies were not recognized by H & E stain but were distinctly stained in a ring-like structure (thus "ring bodies") by Victoria blue or aldehyde-fuchsin stain. They seemed to contain phospholipid and were related to lysozomes from the results of many histochemical stainings and positive acid phospahatase activity. Electron-microscopically, the "ring bodies" might correspond to markedly enlarged and vacuolic lipofusucin-like structures. A study of frequency of "ring body" in 650 cases of liver biopsies was done. The results were as follows: chronic hepatitis non-A/non-B (NANB-CH) 63/191 (33%), B-CH 6/129 (5%), alcoholic type liver disease (ALD) 32/111 (29%), ALD+NANB-CH 11/23 (48%), ALD+B-CH 1/4 (25%), primary biliary cirrhosis 0/43 (0%), lupoid hepatitis 0/17 (0%), others 2/75 (3%). In 47 cases of post-transfusion NANB-CH, "ring bodies" were found in 27 cases (57%). In 57 cases of acute hepatitis, "ring bodies" were found in only three cases (5%). These three positive cases were post-transfusion hepatitis (NANB), all of which were clinically suspected to become chronic. In conclusion, "ring body" is a newly-discovered inclusion body which may be utilized as a histological marker of NANB-CH, ALD and chronicity of NANB-AH.

収録刊行物

  • 肝臓

    肝臓 27 (7), 945-952, 1986

    一般社団法人　日本肝臓学会

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