A Multicenter Study on the Prognosis and Indications of Liver Transplantation for Fulminant Hepatitis in Japan. Details of Decision of the Guideline for Liver Transplantation in Japanese Acute Hepatic Failure Study Group (1996).

DOI Web Site 24 Citations 28 References
  • SUGIHARA Jun-ichi
    First Department of Internal Medicine, Gifu University School of Medicine the 22th meeting of Japanese Acute Hepatic Failure Study Group
  • NAITO Tomoo
    First Department of Internal Medicine, Gifu University School of Medicine
  • ISHIKI Yoshihide
    First Department of Internal Medicine, Gifu University School of Medicine
  • MURAKAMI Nobuo
    First Department of Internal Medicine, Gifu University School of Medicine
  • NAIKI Takafumi
    First Department of Internal Medicine, Gifu University School of Medicine
  • KOSHINO Yousuke
    First Department of Internal Medicine, Gifu University School of Medicine
  • SHIRATORI Yoshimune
    First Department of Internal Medicine, Gifu University School of Medicine
  • ANDO Kazuki
    First Department of Internal Medicine, Gifu University School of Medicine
  • NAGAKI Masahito
    First Department of Internal Medicine, Gifu University School of Medicine
  • OHNISHI Hiroo
    First Department of Internal Medicine, Gifu University School of Medicine
  • MORIWAKI Hisataka
    First Department of Internal Medicine, Gifu University School of Medicine
  • MUTO Yasutoshi
    First Department of Internal Medicine, Gifu University School of Medicine Incurable Hepatitis Research Group, the Ministry of Health and Welfare Fulminant Hepatitis Research Group, the Ministry of Health and Welfare
  • YOSHIBA Makoto
    the 22th meeting of Japanese Acute Hepatic Failure Study Group Division of Gastroenterology, Showa University, Fujigaoka Hospital
  • FUJIWARA Kenji
    Third Department of Internal Medicine, Saitama Medical School Japanese Acute Hepatic Failure Study Group
  • TANIKAWA Kyuuichi
    Second Department of Internal Medicine, Kurume University School of Medicine Japanese Indication of Liver Transplantation Study Group

Bibliographic Information

Other Title
  • わが国における劇症肝炎の予後予測と肝移植の適応に関する多施設研究　　日本急性肝不全研究会１９９６年肝移植適応ガイドライン策定の経緯
  • Details of Decision of the Guideline for Liver Transplantation in Japanese Acute Hepatic Failure Study Group (1996)
  • 日本急性肝不全研究会1996年肝移植適応ガイドライン策定の経緯

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Description

We prepared a guideline for indication of liver transplantation for fulminant hepatitis (FH) retrospectively by multivariate analysis of multicenter data and, then, conducted a prospective evaluation of the guideline by questionnaire survey. In the guideline, patients were registered as candidates of liver transplantation and recommended transplant if possible, when 2 or more of the following 5 criteria were fulfilled at the onset of hepatic encephalopathy (HE): 1) age of 45 years or above, 2) interval from appearance of initial symptoms to the onset of HE of 11 days or longer, 3) prothrombin time (PT) of less than 10%, 4) serum total bilirubin concentration of 18.0mg/dl or above, 5) direct/total bilirubin ratio of 0.67 or less. If liver transplantation was unable within 5 days, the patients were re-predicted to survive 1) when coma grade of HE was improved to grade 1 or less or by 2 or more grades and 2) when PT improved above 50% during this period; they were otherwise re-predicted to die and kept registered. When this guideline was tested prospectively, predictive accuracy was 0.82. This guideline is useful for evaluation of indications of liver transplantation for FH in Japan.

Journal

  • Kanzo

    Kanzo 42 (10), 543-557, 2001

    The Japan Society of Hepatology

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