Efficacy of flumazenil, a benzodiazepine antagonist, in patients with alcoholic liver cirrhosis complicating hepatic encephalopathy.

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  • KOGA Yuriko
    The Second Department of lnternal Medicine, Kurume Univensity School of Medicine
  • SATA Michio
    The Second Department of lnternal Medicine, Kurume Univensity School of Medicine
  • IKEJIRI Naoki
    Internal Medicine, Oita Yuai Hospital
  • SAKAI Megumi
    Internal Medicine, Oita Yuai Hospital
  • KUMASHIRO Ryukichi
    The Second Department of lnternal Medicine, Kurume Univensity School of Medicine
  • ABE Hirohiko
    Internal Medicine, Kumamoto Central Hospital
  • TANIKAWA Kyuichi
    The Second Department of lnternal Medicine, Kurume Univensity School of Medicine

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Other Title
  • アルコール性肝硬変に伴う肝性脳症に対するフルマゼニル投与の有用性の検討

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Description

The Ievels of plasma benzodiazepine (BZ) -1ike substance in patients with hepatic encephalopathy (HE) are recently reported to be increased in serum and cerebrospinal fluid and this is assumed as one of the cause of HE.<BR>We investigated the efficacy of flumazenil, a specific antagonist of brain BZ receptor, in ten patients of alcoholic liver cirrhosis with HE. Flumazenil was administered intravenously as a bolus. Changes of HE grade and electroencephalogram (EEG) were recorded. Improvement of HE was observed in six patients, two patients had no relapse of HE, but in the other four patients, the effect continued for 30-120 minutes and then HE recurred. Improvement of EEG was noticed in six patients. Flumazenil is not a therapy for liver failure itself. However, it is useful to control the patients with HE.

Journal

  • Kanzo

    Kanzo 38 (4), 220-224, 1997

    The Japan Society of Hepatology

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