C型慢性肝炎のPEG‐IFN α‐2b/ribavirin併用療法における亜鉛投与のALT値改善効果(投与開始8週目までの検討)

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  • Zinc supplementation improves ALT level in chronic hepatitis C patients during combination therapy of PEG-interferon .ALPHA.-2b and ribavirin

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We investigated the effects of zinc supplementation on the clinical observations in chronic hepatitis C patients during PEG-interferon α-2b plus ribavirin (PEG-IFN/R) therapy. Patients were randomly allocated to receive daily 150 mg polaprezinc (Zn group, n=11) or no supplement (control, n=12) in addition to PEG-IFN/R therapy and daily antioxidant vitamin supplementation (300 mg of vitamin E and 600 mg of vitamin C). Ten of 11 patients (91%) in Zn group and 7 of 12 (58%) control patients showed decrease in ALT levels (</=35 U/l) after 8 weeks of therapy. This observation indicates that polaprezinc supplementation may induce antioxidative functions in liver which resulted in improvement of hepatocyte injury during PEG-IFN/R therapy.

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  • 肝臓

    肝臓 47 (3), 165-, 2006

    一般社団法人 日本肝臓学会

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