ＨＢウイルスのａｌｂｕｍｉｎ　ｒｅｃｅｐｔｏｒ活性（ｐＨＳＡ‐ＢＡ）によるＢ型肝炎における抗ウイルス剤と免疫賦活剤投与適応例の選択法

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タイトル別名
  • Selection of effective cases in hepatitis B patients for treatments by anti-viral agent and immunopotentiator: Inhibition of binding-activity against albumin receptor on HB virus by adenine arabinoside and OK-432
  • HB ウイルス ノ albumin receptor カッセイ pHSA-BA

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抄録

For selection of effective cases in hepatitis B patients for treatments by anti-viral agent and immunopotentiator, the binding-activity of albumin receptor on hepatitis B virus (HBV) (pHSA-BA) assay was used. The patient sera at 3, 6, 12, 24, 48 hours after one shot of adenine arabinoside (Ara-A: 5 mg/kg) or bacterial immunopotentiator (OK-432: 2.0KE) were tested. On the otherhand, the sera from 3 groups of Ara-A administration, OK-432 administration and combination administration with Ara-A and Ok-432 for 3 to 10 weeks were tested. As the results, one shot of Ara-A was no effective against the titers of HBeAg and pHSA-BA, and on the contrary indicated to decrease the titers of anti-HBe. On the other hand, one shot of OK-432 was effective against the titers of both HBeAg and pHSA-BA. In the 3 groups, the combination group with Ara-A and OK-432 was most effective against pHSA-BA. These results indicated that the pHSA-BA assay was useful for selection of effective cases in hepatitis B patients before administration of anti-viral agent or immunopotentiator in place of the conventional tests for HBV infectious markers (e.g. DNA polymerase activity, HBeAg, Dane particles).

収録刊行物

  • 肝臓

    肝臓 24 (3), 278-284, 1983

    一般社団法人　日本肝臓学会

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