The existence of cholestatic factor in the serum from a patient with liver cirrhosis
-
- MIZOGUCHI Yasuhiro
- The Third Department of Internal Medicine, Osaka City University Medical School
-
- TSUTSUI Hiroko
- The Third Department of Internal Medicine, Osaka City University Medical School
-
- SAKAGAMI Yoshihide
- The Third Department of Internal Medicine, Osaka City University Medical School
-
- SHIBA Takashi
- The Third Department of Internal Medicine, Osaka City University Medical School
-
- KANNO Tohru
- The Third Department of Internal Medicine, Osaka City University Medical School
-
- HIGASHIMORI Toshihiro
- The Third Department of Internal Medicine, Osaka City University Medical School
-
- NAKAO Masahiro
- The Third Department of Internal Medicine, Osaka City University Medical School
-
- HARIHARA Shigeyuki
- The Third Department of Internal Medicine, Osaka City University Medical School
-
- MONNA Takeyuki
- The Third Department of Internal Medicine, Osaka City University Medical School
-
- YAMAMOTO Sukeo
- The Third Department of Internal Medicine, Osaka City University Medical School
-
- IMOTO Masami
- The Third Department of Internal Medicine, Osaka City University Medical School
-
- MITSUHASHI Takehiro
- The Second Department of Pathology, Osaka City University Medical School
-
- MORISAWA Seiji
- The First Department of Biochemistry, Osaka City University Medical School
Bibliographic Information
- Other Title
-
- 肝内胆汁うっ滞を伴うHBs抗原陽性肝硬変患者の血清中に認められた催胆汁うっ滞因子
- カンナイ タンジュウ ウッタイ オ トモナウ HBs コウゲン ヨウセイ カン
Search this article
Description
When the blood serum from a patient with liver cirrhosis was fractionated by a Sephadex G-75 gel filtration and the certain fraction was injected into mesenteric vein of rats, a marked reduction of bile flow was seen. Similar results were obtained when peripheral lymphocytes from the patient were stimulated with HBs antigen or liver specific lipoprotein in vitro and the certain fraction which was fractionated with a Sephadex G-75 gel filtration was injected into mesenteric vein of rats. Histologically, a dilated bile canaliculus with the diminution of microvilli and increased vesicles around the dilated canaliculi were observed by an electron microscopy after injection of culture supernatant fraction into rats.<BR>These results strongly suggest that not only the sensitized lymphocytes produce the cholestatic factor (factors) which causes the intrahepatic cholestasis, but also this factor involves significantly in the pathogenesis or intrahepatic cholestasis which observes in the patient with liver cirrhosis.
Journal
-
- Kanzo
-
Kanzo 23 (2), 125-131, 1982
The Japan Society of Hepatology
- Tweet
Details 詳細情報について
-
- CRID
- 1390001204791309696
-
- NII Article ID
- 130000878172
-
- NII Book ID
- AN00047770
-
- ISSN
- 18813593
- 04514203
-
- NDL BIB ID
- 2482292
-
- Text Lang
- ja
-
- Data Source
-
- JaLC
- NDL
- Crossref
- CiNii Articles
-
- Abstract License Flag
- Disallowed