The existence of cholestatic factor in the serum from a patient with liver cirrhosis

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  • MIZOGUCHI Yasuhiro
    The Third Department of Internal Medicine, Osaka City University Medical School
  • TSUTSUI Hiroko
    The Third Department of Internal Medicine, Osaka City University Medical School
  • SAKAGAMI Yoshihide
    The Third Department of Internal Medicine, Osaka City University Medical School
  • SHIBA Takashi
    The Third Department of Internal Medicine, Osaka City University Medical School
  • KANNO Tohru
    The Third Department of Internal Medicine, Osaka City University Medical School
  • HIGASHIMORI Toshihiro
    The Third Department of Internal Medicine, Osaka City University Medical School
  • NAKAO Masahiro
    The Third Department of Internal Medicine, Osaka City University Medical School
  • HARIHARA Shigeyuki
    The Third Department of Internal Medicine, Osaka City University Medical School
  • MONNA Takeyuki
    The Third Department of Internal Medicine, Osaka City University Medical School
  • YAMAMOTO Sukeo
    The Third Department of Internal Medicine, Osaka City University Medical School
  • IMOTO Masami
    The Third Department of Internal Medicine, Osaka City University Medical School
  • MITSUHASHI Takehiro
    The Second Department of Pathology, Osaka City University Medical School
  • MORISAWA Seiji
    The First Department of Biochemistry, Osaka City University Medical School

Bibliographic Information

Other Title
  • 肝内胆汁うっ滞を伴うＨＢｓ抗原陽性肝硬変患者の血清中に認められた催胆汁うっ滞因子
  • カンナイ タンジュウ ウッタイ オ トモナウ HBs コウゲン ヨウセイ カン

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Description

When the blood serum from a patient with liver cirrhosis was fractionated by a Sephadex G-75 gel filtration and the certain fraction was injected into mesenteric vein of rats, a marked reduction of bile flow was seen. Similar results were obtained when peripheral lymphocytes from the patient were stimulated with HBs antigen or liver specific lipoprotein in vitro and the certain fraction which was fractionated with a Sephadex G-75 gel filtration was injected into mesenteric vein of rats. Histologically, a dilated bile canaliculus with the diminution of microvilli and increased vesicles around the dilated canaliculi were observed by an electron microscopy after injection of culture supernatant fraction into rats.<BR>These results strongly suggest that not only the sensitized lymphocytes produce the cholestatic factor (factors) which causes the intrahepatic cholestasis, but also this factor involves significantly in the pathogenesis or intrahepatic cholestasis which observes in the patient with liver cirrhosis.

Journal

  • Kanzo

    Kanzo 23 (2), 125-131, 1982

    The Japan Society of Hepatology

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