Asymptomatic intrahepatic sclerosing cholangitis.

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  • HIRAI Nobuyuki
    The First Department of Internal Medicine, School of Medicine, Kanazawa University
  • NAKANUMA Yasuni
    The Second Department of Pathology, School of Medicine, Kanazawa University
  • YONESHIMA Manabu
    The First Department of Internal Medicine, School of Medicine, Kanazawa University
  • KITAGAWA Hirofumi
    The First Department of Internal Medicine, School of Medicine, Kanazawa University
  • TANAKA Nobuyoshi
    The First Department of Internal Medicine, School of Medicine, Kanazawa University
  • KATO Yasuhiro
    The First Department of Internal Medicine, School of Medicine, Kanazawa University
  • KOBAYASHI Kenichi
    The First Department of Internal Medicine, School of Medicine, Kanazawa University
  • HATTORI Nobu
    The First Department of Internal Medicine, School of Medicine, Kanazawa University

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Other Title
  • 無症候性肝内型原発性硬化性胆管炎の１例

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Abstract

A 54 y.o. woman, who is completely asymptomatic, is reported to have primary sclerosing cholangitis (PSC) localized in the intrahepatic biliary tree alone. The liver function disorder was noticed by chance, representing a marked cholestatic pattern with slightly elevated IgM and weakly positive anti-mitochondrial antibody (AMA). The liver histology showed bile duct loss and ductular proliferation with lympho-plasmocytic infiltration in the portal tract. She was then diagnosed as a probable primary biliary cirrhosis (PBC) and treated with D-penicillamine. After about 4 years, during which the levels of the bile duct enzymes and IgM gradually dropped, her liver disease was re-evaluated. The liver histology showed mild ductular changes and portal fibrosis. AMA was not detectable. ERCP showed a diffuse costricturing and beaded appearances of the intrahepatic biliary tree, whereas the extrahepatic biliary system was normal. The diagnosis of intrahepatic PSC was finally made.

Journal

  • Kanzo

    Kanzo 27 (4), 515-522, 1986

    The Japan Society of Hepatology

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