A case of chronic hepatitis C with interstitial pneumonitis after interferon .ALPHA.-2b administration during a long-term administration of sho-saiko-to.

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  • OGIHARA Takehide
    The Third Department of Internal Medicine, Fuculty of Medicine, University of Tokyo
  • OONISHI Shin
    The Third Department of Internal Medicine, Fuculty of Medicine, University of Tokyo
  • MIURA Hideaki
    The Third Department of Internal Medicine, Fuculty of Medicine, University of Tokyo
  • KITA Hiroto
    The Third Department of Internal Medicine, Fuculty of Medicine, University of Tokyo
  • NAKAMURA Ikuo
    The Third Department of Internal Medicine, Fuculty of Medicine, University of Tokyo
  • MATSUHASHI Nobuyuki
    The Third Department of Internal Medicine, Fuculty of Medicine, University of Tokyo
  • KODAMA Tatsuhiko
    The Third Department of Internal Medicine, Fuculty of Medicine, University of Tokyo
  • IMAWARI Michio
    Department of Gastroenterology, Jichi Medical College
  • YAZAKI Yoshio
    The Third Department of Internal Medicine, Fuculty of Medicine, University of Tokyo
  • OKA Teruaki
    The Third Department of Internal Medicine, Fuculty of Medicine, University of Tokyo
  • MACHINAMI Rikuo
    The First Department of Pathology, Fuculty of Medicine, University of Tokyo

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Other Title
  • 小柴胡湯を長期服用中，インターフェロンα・２ｂを併用投与後に間質性肺炎を呈したＣ型慢性肝炎の１例

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Description

The patient was a 57-year-old male who had received syo-saiko-to due to liver dysfunction since 1983. He was diagnosed chronic hepatitis C in 1992 and administered interferon (IFN) α-2b 9MIU for 48 times. After the administration of IFN α-2b, the symptom of interstitial pneumonitis appeared. After the all medications were stopped, the symptoms and radiological findings were improved. The result of lymphocyte stimulation test was negative for IFN α-2b, but IFN-induced pneumonitis was strongly suspected from the clinical course. It should be noticed that IFN α-2b may induce interstitial pneumonitis, especially during the administration of sho-saiko-to like this case.

Journal

  • Kanzo

    Kanzo 35 (4), 302-308, 1994

    The Japan Society of Hepatology

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