Relations among Symptoms and Sleep, Urinary Prostaglandin E2 Pattern in Patients after Esophagectomy

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  • 食道がん術後患者におけるせん妄症状・睡眠・尿中ＰＧＥ２排泄パターンの関係
  • ショクドウ ガン ジュツゴ カンジャ ニ オケル センモウショウジョウ スイミン ニョウ チュウ PGE2 ハイセツ パターン ノ カンケイ

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The purpose of this study was to clarify the relationships among delirium, sleep–awake patterns and urinary excretion of prostaglandin in patients after surgery. The subjects were 19 men (mean age, 64.7 years age) who had undergone total esophagectomy (with right thoracotomy) for cancer of the thoracic esophagus. Post-operative delirium was classified into 11 behaviors and the sleep-awake state was graded into four categories. Urinary excretion of prostaglandin E2 was determined using an EIA kit.<br>The results showed a regular sleep–awake pattern in the non-delirium group (n=10). In contrast, the delirium symptoms group (n=9) showed irregular sleep–awake patterns on postoperative days 1–3. In addition, only nine of the symptoms of postoperative delirium occurred at the time, or before, the sleep–awake pattern changed. Urinary excretion of prostaglandin E2 increased only on postoperative day one in the non-delirium group, whereas it increased throughout the observation period in the delirium symptoms group. These results suggest that a nocturnal sleep disorder and the presence of urinary prostaglandin affect the occurrence of postoperative delirium.

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