Clinical Relevance of Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy for the Cirrhotic without Overt Hepatic Encephalopathy.

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  • 肝性脳症のない肝硬変における磁気共鳴画像（ＭＲＩ）と磁気共鳴分析法（ＭＲＳ）の測定意義

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To clarify the changes of pallidal high intensity on T1-weighted magnetic resonance imaging (MRI) and brain metabolites on magnetic resonance spectroscopy (MRS) as related to the severity of hepatic functions, the concentrations of blood ammonia (B-NH3) and the levels of trace elements (Mn, Cu and Zn), 30 patients with liver cirrhosis without hepatic encephalopathy (HE) and 5 age-matched healthy control subjects underwent MRI and proton MRS. Pallidal high intensity (Pl index) and glutamine are higher in cirrhosis, and myo-inositol is lower than that of control statistically. In cirrhosis, there were statistically negative correlation between B-NH3 and myo-inositol and positive correlation between B-NH3 and glutamine. There was a statistically lower myo-inositol and higher Pl index, glutamine as the severity of hepatic functions increased. Furthermore there was a statistically positive correlation between Pl index and Mn. These data suggest that the changes of MRI and MRS findings already detected in cirrhosis without HE and these abnormalities may be reflect the B-NH3 and Mn metabolism and the severity of the hepatic functions.

Journal

  • Kanzo

    Kanzo 40 (4), 235-242, 1999

    The Japan Society of Hepatology

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