Successful treatment with interferon for a HCV-RNA positive patient with features of "autoimmune hepatitis".
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- SOGA Makoto
- The First Department of Internal Medicine, Kochi Medical School
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- YAMASAKI Hisao
- The First Department of Internal Medicine, Kochi Medical School
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- TOMITA Akira
- The First Department of Internal Medicine, Kochi Medical School
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- IWAMURA Shinichi
- The First Department of Internal Medicine, Kochi Medical School
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- IWASAKI Shinji
- The First Department of Internal Medicine, Kochi Medical School
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- MAEDA Takashi
- The First Department of Internal Medicine, Kochi Medical School
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- MIYAZAKI Masako
- The First Department of Internal Medicine, Kochi Medical School
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- ONISHI Saburo
- The First Department of Internal Medicine, Kochi Medical School
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- YAMAMOTO Yasutake
- The First Department of Internal Medicine, Kochi Medical School
Bibliographic Information
- Other Title
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- 典型的な自己免疫性肝炎の病像を示し,インターフェロンが有効であったHCV‐RNA陽性慢性活動性肝炎の1例
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Abstract
A case of 55 year-old woman was admitted to our hospital because of general malaise in November 1990. She had episodes of struma and chronic liver disease for last seven years. Two months before admission, serum ALT (SGPT) was elevated to greater than 200 IU per liter. On admission, she was diagnosed as autoimmune hepatitis based on findings of CAH2B with severe plasma cell infiltrasion, an increased level of serum gammaglobulin and high titers of antinuclear antibodies. Her HLA typing was positive for DR4. Corticosteroid therapy was effective to decrease levels of SGPT and gamma globulin. Tapering prednisolone resulted in gradual elevation of SGPT and gammaglobulin levels. Since HCV-RNA was detected positive at this point, administration of interferon-α (6 MU/day) strated. About three months later, SGPT level drastically decreased, and antinuclear antibodies and HCV-RNA became undertectable. Although this case showed characteristics of "autoimmune hepatitis", effectiveness of interferon therapy strongly suggested that HCV played a pathogenic role.
Journal
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- Kanzo
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Kanzo 33 (7), 548-551, 1992
The Japan Society of Hepatology
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Details 詳細情報について
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- CRID
- 1390001204792006912
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- NII Article ID
- 130000877828
- 80006593264
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- NII Book ID
- AN00047770
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- ISSN
- 18813593
- 04514203
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed