Diagnosis of acute hepatitis B by measurement of anti-HBc IgM

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  • ＩｇＭ型ＨＢｃ抗体によるＢ型急性肝炎の診断についての検討
  • IgMガタ HBc コウタイ ニヨル Bガタ キュウセイ カンエン ノ シンダ

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Abstract

To determine the diagnostic value of anti-HBc IgM in acute viral hepatitis or chronic hepatitis B, the sera of 29 patients with known acute hepatitis B, of 24 patients with known chronic hepatitis B, and of 32 patients with acute hepatitis found negative for HBsAg and negative for IgM antibody against hepatitis A, were studied for anti-HBc IgM by Radioimmunoassay.<BR>Anti-HBc IgM was found in all of the 62 sera of acute hepatitis B for 12 weeks from the onset of the illnes, and its value was especially higher (19.0±5.9) for 6 weeks from the onset.<BR>Anti-HBc IgM was found in 61 (95.3%) of 64 sera of chronic hepatitis B, but its value was low (3.9±1.9). So, its value was higher in acute hepatitis B for 6 weeks from the onset of the illnes than in chronic hepatitis B (p<0.0001).<BR>Anti-HBc IgM was found in 6 (18.8%) of 32 patients with acute hepatitis found negative for HBsAg and negative for IgM antibody against hepatitis A, and its value was high. So, the 6 cases were thought acute hepatitis B.<BR>Thus, anti-HBc IgM seems to be a specific serological marker of hepatitis B virus infection. And it may be useful in differentiation between acute hepatitis B with or without HBsAg and acute non B hepatitis, and help differentiate acute from chronic infection in HBsAg positive patients.

Journal

  • Kanzo

    Kanzo 24 (5), 485-491, 1983

    The Japan Society of Hepatology

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