A case of acute onset autoimmune hepatitis complicated with low T3 syndrome.

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  • NAGAI Kazuki
    Second Department of Internal Medicine, Toho University School of Medicine
  • YAMAMURO Wataru
    Second Department of Internal Medicine, Toho University School of Medicine
  • KUBO Shuichi
    Second Department of Internal Medicine, Toho University School of Medicine
  • YOSHIDA Naoya
    Second Department of Internal Medicine, Toho University School of Medicine
  • SATOH Takashi
    Second Department of Internal Medicine, Toho University School of Medicine
  • HATORI Tomoki
    Second Department of Internal Medicine, Toho University School of Medicine
  • SUMINO Yasukiyo
    Second Department of Internal Medicine, Toho University School of Medicine
  • SUGIMOTO Motonobu
    Second Department of Internal Medicine, Toho University School of Medicine
  • NONAKA Hiroko
    First Department of Pathology, Toho University School of Medicine

Bibliographic Information

Other Title
  • 経過中に著明なｌｏｗ　Ｔ３症候群を来した急性発症型自己免疫性肝炎の１例

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Description

A 70-year-old woman was admitted to our hospital with general fatigue, anorexia and jaundice. Laboratory data on admission revealed acute hepatitis like abnormality such as GOT 1453IU/l, GPT 1031IU/l and total bilirubin 8.4mg/dl. There was no evidence of viral hepatitis type A, B or C. She was diagnosed as acute phase of autoimmune hepatitis because of increased serum IgG level (4246mg/dl), and positive serum anti-nuclelar-antibody. The liver biopsy specimen showed chronic active hepatitis.<BR>Since the serum level of free-T3 on admission was very low (1.36pg/dl) while those of free-T4 and TSH were normal, she was diagnosed to be complicated with low T3 syndrome. The oral administration of prednisolone started from 40mg/day improved her symptoms and abnormality of liver function tests. However, the serum F-T3 level was once decreased to undertactable level and then gradually increased with the tapering of prednisolone dosage.<BR>It is suggested that low T3 syndrome is associated with acute onset autoimmune hepatitis and it is accelerated by the corticosteroid hormone therapy.

Journal

  • Kanzo

    Kanzo 34 (2), 156-160, 1993

    The Japan Society of Hepatology

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