蛋白同化ホルモン剤による再生不良性貧血治療中に発生したと思われる肝細胞腺腫の1例

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タイトル別名
  • A case of hepatocellular adenoma associated with anabolic steroids therapy for aplastic anemia
  • タンパク ドウカ ホルモンザイ ニヨル サイセイ フリョウセイ ヒンケツ チリ

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The patient, a 4 1/4-year-old girl, was diagnosed as aplastic anemia and treated for 2 1/3 years with androgenic anabolic steroids (Winstrol, Enarmon and Enarmon depot). She died of diabetic coma. At autopsy, a 2.0×2.0×1.5 cm sized tumor was found in the right lobe of the liver. This tumor was sharply demarcated from the surrounding tissue, but had no fibrous capsule. Histologically, it was divided irregularly with loose conective tissues and composed of mature hepatocytes, which were arranged in two-cell plates and partly in tubular structures. There was no histological evidence of viral hepatitis and cirrhosis. A diagnosis of hepatocellular adenoma was made and it was considered to be induced by androgenic anabolic steroids. In the past literatures, 16 cases of liver tumors due to androgenic anabolic steroids were reported. And recently there has been increasing number of reports concerning association between oral contraceptives and liver tumors. These kinds of steroids have similar chemical structure and the liver tumors induced by them have very similar histological pattern. However various terms were used for those lesions. Therefore, we reported the present case with some discussions.

収録刊行物

  • 肝臓

    肝臓 18 (12), 958-964, 1977

    一般社団法人　日本肝臓学会

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