慢性肝疾患時の糖脂質代謝に対する糖質コルチコイドの影響

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タイトル別名
  • The effects of glucocorticoid on carbohydrate and lipid metabolism in chronic liver disease
  • マンセイ カン シッカンジ ノ トウ シシツ タイシャ ニ タイスル トウシツ

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抄録

Impaired glucose tolerance were observed in patients with chronic hepatitis treated with glucocorticoid, but not observed in patients without liver disease receiving glucocorticoid. <BR>Increment of insulin response to oral glucose were obsurved in patients with chronic hepatitis treated with glucocorticoid or not, liver cirrhosis, and patients without liver disease receiving glucocorticoid. <BR>Either ΔIRI or Δglucose increased in patientswith chronic hepatitis and liver cirrhosis but ΔIRI in patients without liver disease receiving glucocorticoid, extremely elevated, and glucose level was same as control. In patients with chronic hepatitis treated with glucocorticoid decrement of ΔIRI and increment of glucose were observed. <BR>The elevation of fasting FFA level were observed only in patients with liver cirrhosis. <BR>The increment of triglyceraid level were observed in patients without liver disease receiving glucocorticoid. <BR>These results indicate that there are hormonal disturbance and different mechanism of glucocorticoid effects in chronic liver disease.

収録刊行物

  • 肝臓

    肝臓 18 (11), 838-846, 1977

    一般社団法人　日本肝臓学会

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