Scanning and transmission electron microscopic observations of cirrhotic liver sinusoids in man and rat

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  • ヒトおよび実験的肝硬変における肝類洞の電顕的観察
  • ヒト オヨビ ジッケンテキ カンコウヘン ニ オケル カン ルイドウ ノ デン

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Liver specimens, from rats with cirrhosis induced by long term administration of CCI4 and from man with cirrhosis, were examined under scanning (SEM) and transmission (TEM) electron microscopies. <BR>SEM revealed cirrhotic liver sinusoids, in man and rat, to become narrow by compression due to regenerated hepatocytes, hypertrophied Kupffer cell, and distend space of Disse with abundunt proliferated celluler components and collagen fibers. Furthermore, pores of the sinusoidal endothelium were partly reduced in number. <BR>On the other hand, TEM disclosed a development of basement membrane within the space of Disse and the endothelial cell layer appeared to be continuous in part. <BR>It could be concluded from these data that these changes represent the circulatory disadvantage to the hepatocytes, resulting in further hepatocellular injury in cirrhosis.

Journal

  • Kanzo

    Kanzo 18 (11), 803-813, 1977

    The Japan Society of Hepatology

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