Spontaneous negativation of serum hepatitis C virus RNA in type C chronic liver disese: A retrospective study

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  • C型慢性肝疾患患者におけるC型肝炎ウイルス自然陰性化：当院での後ろ向き研究
  • Cガタ マンセイ カン シッカン カンジャ ニ オケル Cガタカンエンウイルス シゼン インセイカ : トウ イン デ ノ ウシロ ムキ ケンキュウ

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Abstract

The natural course of hepatitis C virus (HCV) infection has not been systematically studied. To investigate the frequency and factors of spontaneous elimination of HCV in chronic carriers, we conducted a retrospective study on 278 chronic HCV carriers without antiviral therapy between April 2006 and February 2014. The mean follow up duration was 5.8 years. Serum HCV RNA was spontaneously eliminated in 4/278 (1.44%). Thus, the incidence of spontaneous negativation of HCV RNA was 0.24%/year/person. Univariate analysis revealed that low values of serum HCV RNA, ALT, γGTP, total bilirubin, AST to platelet ratio index (APRI), and a high value of platelet count were associated with spontaneous viral elimination. IL28B single nucleotide polymorphisms (rs8099917, rs11881222, rs8103142) of all the four patients who cleared virus were major alleles. In addition, every spontaneous HCV clearance was observed after surgery or drug induced hepatitis or colonic diverticular hemorrhage.

Journal

  • Kanzo

    Kanzo 56 (8), 414-421, 2015

    The Japan Society of Hepatology

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