A severe drug induced hepatitis caused by a dietary supplement "Nin-niku Ran-oh" made from garlic and egg yolk

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  • Okamoto Kinya
    Second Department of Internal Medicine, Tottori University School of Medicine
  • Miyoshi Ken-ichi
    Second Department of Internal Medicine, Tottori University School of Medicine
  • Kishina Manabu
    Second Department of Internal Medicine, Tottori University School of Medicine
  • Fujise Yuki
    Second Department of Internal Medicine, Tottori University School of Medicine
  • Kato Jyun
    Second Department of Internal Medicine, Tottori University School of Medicine
  • Tokunaga Shiho
    Second Department of Internal Medicine, Tottori University School of Medicine
  • Matono Tomomitsu
    Second Department of Internal Medicine, Tottori University School of Medicine
  • Hosyo Keiko
    Second Department of Internal Medicine, Tottori University School of Medicine
  • Oyama Kenji
    Second Department of Internal Medicine, Tottori University School of Medicine
  • Okano Jyun-ichi
    Second Department of Internal Medicine, Tottori University School of Medicine
  • Maeda Naoto
    Second Department of Internal Medicine, Tottori University School of Medicine
  • Koda Masahiko
    Second Department of Internal Medicine, Tottori University School of Medicine
  • Murawaki Yoshikazu
    Second Department of Internal Medicine, Tottori University School of Medicine

Bibliographic Information

Other Title
  • 健康食品「にんにく卵黄」によると思われる薬物性肝障害の1例
  • ショウレイ ホウコク ケンコウ ショクヒン 「 ニンニクランオウ 」 ニ ヨル ト オモワレル ヤクブツセイ カン ショウガイ ノ 1レイ

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Description

Dietary supplements are easily available and increasingly used, and adverse hepatic reactions have been reported following their intake.<br> A 60 years old woman who took some dietary supplements developed appetite loss, general fatigue, jaundice and subcutaneous hemorrhage together with a > 40-fold increase of transaminase levels and prothrombin time elongation. There were no evidence of viral hepatitis, autoimmune, metabolic or alcohol-related liver disorders. Drug-induced lymphocyte stimulation test was positive to the dietary supplement "Nin-niku Ran-oh", which is made from garlic and egg yolk. DDW-J 2004 drug-induced liver injury score was 10 and diagnosed as highly probable. Seven weeks after discontinuation of the supplements, the liver functions recovered to normal.<br>

Journal

  • Kanzo

    Kanzo 53 (11), 748-753, 2012

    The Japan Society of Hepatology

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