Proposal of the radicality grading as a criterion for therapeutic effectiveness of RFA against hepatocellular carcinoma, in relation to the local recurrence rate

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  • Nishijima Norihiro
    Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital
  • Ohsaki Yukio
    Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital
  • Kita Ryuichi
    Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital
  • Esoh Yuji
    Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital
  • Yamanaka Shinichi
    Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital
  • Kawakami Hisato
    Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital
  • Saitoh Sumio
    Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital
  • Hatano Kiyoaki
    Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital
  • Matsuo Hiroo
    Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital
  • Nakatsuji Masato
    Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital
  • Ikeda Atsuyuki
    Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital
  • Nishikawa Hiroki
    Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital
  • Maruo Takanori
    Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital
  • Okabe Yoshihiro
    Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital
  • Kimura Tohru
    Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital

Bibliographic Information

Other Title
  • 肝細胞癌に対するＲＦＡにおける効果判定基準の提唱‐局所再発率の検討から‐
  • 肝細胞癌に対するRFAにおける効果判定基準の提唱--局所再発率の検討から
  • カン サイボウ ガン ニ タイスル RFA ニ オケル コウカ ハンテイ キジュン ノ テイショウ キョクショ サイハツリツ ノ ケントウ カラ

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Description

PURPOSE: We classified the radicality of Radio Frequency Ablation (RFA) according to the extent of ablated area around the nodules, and measured the local recurrence rate for each radicality grade to examine its significance as a criterion for assessing the therapeutic effectiveness of RFA. METHOD: 99 nodules of 77 patients treated by Real-time Virtual Sonography-guided RFA were studied. We classified the radicality of the procedure into 4 grades (R grades: R0, R1, R2, and R3) according to the extent and pattern of the ablated area around the nodule, calculated the post-RFA cumulative local recurrence rate for each R number group, and analyzed the factors contributing to local recurrence. The distance of the site of recurrence from the treated nodule was also studied in the cases that showed recurrence. RESULTS: The cumulative local recurrence rate in 2 years was 3.7%, 13.6%, 52.6%, and 66.7% respectively for the R3, R2, R1, and R0 groups. Multivariate analysis showed that the R grade was the only significant independent factor contributing to local recurrence. Of the 25 cases of local recurrence, 20 had recurrence in the part where the ablative margin around the treated nodule was less than 5 mm. CONCLUSION: An ablative margin visible all around the treated nodule, preferably 5 mm or wider at all points, is a criterion for predicting good therapeutic effect of RFA.<br>

Journal

  • Kanzo

    Kanzo 49 (5), 192-199, 2008

    The Japan Society of Hepatology

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