Studies on the HBsAg and HBcAg in the liver tissue

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  • KIYOSAWA Kendo
    The Second Department of Internal Medicine, Shinshu University Medical School

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Other Title
  • 肝組織内HBs抗原・HBc抗原に関する研究
  • カン ソシキナイ HBs コウゲン HBc コウゲン ニカンスルケンキュウ 1
  • Part 1. Studies on the correlation between the expression of HBsAg, HBcAg in the liver and HBsAg, HBsAb, HBcAb, HBeAg and HBeAb in serum
  • 第1編:肝組織内HBs抗原・HBc抗原の局在・分布と血中HBs抗原価,HBc抗体価およびHBe抗原・HBe抗体との関係について

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Abstract

Intrahepatic HBsAg and HBcAg were examined by immunofluorescent method and correlation between the expression of HBsAg, HBcAg in the liver tissue and HBsAg, HBsAb, HBcAb, HBeAg, HBeAb in serum were studied. The localization patterns of intrahepatic HBsAg were classified into membranous, cytoplasmic and mixed pattern.<BR>The distribution patterns of HBsAg in the liver tissue were classified into sporadic, focal and diffuse pattern. HBcAg localized in the nucleus and the cytoplasm arround nucleus of the hepatocyte. In case of high titer of HBsAg in serum, intrahepatic HBsAg revealed membranous localization and diffuse distribution pattern. In case of low titer of HBsAg in serum, intrahepatic HBsAg revealed cytoplasmic localization and sporadic or focal distribution pattern. Intrahepatic HBcAg were detected abundantly in cases with cytoplasmic and mixed localization pattern of intrahepatic HBsAg expression and in HBeAg positive cases. The HBcAb titer in cases with HBcAg in the liver was higher than it in cases without HBcAg in the liver.

Journal

  • Kanzo

    Kanzo 19 (2), 135-147, 1978

    The Japan Society of Hepatology

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