Genotype1b・C型慢性肝炎に対するPeginterferon α-2b/Ribavirin/Telaprevir3剤併用療法のRapid virological responseに寄与する因子の検討：多施設共同試験

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  • Factors contributing to rapid virological response to triple therapy with peginterferon alfa-2b, ribavarin and telaprevir in chronic hepatitis C patients infected with genotype1b: Multicenter trial
  • Genotype1b ・ Cガタ マンセイ カンエン ニ タイスル Peginterferon a-2b/Ribavirin/Telaprevir3ザイ ヘイヨウ リョウホウ ノ Rapid virological response ニ キヨ スル インシ ノ ケントウ : タシセツ キョウドウ シケン

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Rapid virological response (RVR) is very important in achieving sustained virological response (SVR) to triple therapy with peginterferon alfa-2b, ribavirin and telaprevir for chronic hepatitis C. To analyze baseline factors associated with RVR, 128 Japanese patients infected with hepatitis C virus (HCV) genotype1b were subjected to this study. By univariate analysis, prior treatment response (naïve or relapse), high platelet count, low AST level, low viral load contributed significantly to RVR. By multivariate analysis, prior treatment (naïve or relapse) and low viral load were significant independent factors. Further investigation is required to clarify whether these factors may contribute to SVR and develop novel individualized treatment algorithm.<br>

収録刊行物

  • 肝臓

    肝臓 53 (10), 627-632, 2012

    一般社団法人　日本肝臓学会

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