A case of hepatitis C virus-associated mixed cryoglobulinemic vasculitis treated with daclatasvir and asunaprevir

  • Takada Sayuri
    Department of Gastoroenterology, Kashiwara Municipal Hospital
  • Uchida-Kobayashi Sawako
    Department of Hepatology, Graduate School of Medicine, Osaka City University
  • Iida-Ueno Ayako
    Department of Hepatology, Graduate School of Medicine, Osaka City University
  • Teranishi Yuga
    Department of Hepatology, Graduate School of Medicine, Osaka City University
  • Motoyama Hiroyuki
    Department of Hepatology, Graduate School of Medicine, Osaka City University
  • Kozuka Ritsuzo
    Department of Hepatology, Graduate School of Medicine, Osaka City University
  • Kawamura Etsushi
    Department of Hepatology, Graduate School of Medicine, Osaka City University
  • Hagihara Atsushi
    Department of Hepatology, Graduate School of Medicine, Osaka City University
  • Ishizu Hirotaka
    Department of Gastoroenterology, Kashiwara Municipal Hospital
  • Morikawa Hiroyasu
    Department of Hepatology, Graduate School of Medicine, Osaka City University
  • Enomoto Masaru
    Department of Hepatology, Graduate School of Medicine, Osaka City University
  • Murakami Yoshiki
    Department of Hepatology, Graduate School of Medicine, Osaka City University
  • Tamori Akihiro
    Department of Hepatology, Graduate School of Medicine, Osaka City University
  • Kawada Norifumi
    Department of Hepatology, Graduate School of Medicine, Osaka City University

Bibliographic Information

Other Title
  • ダクラタスビル/アスナプレビル治療が著効したクリオグロブリン血管炎合併C型慢性肝疾患の一例
  • 症例報告 ダクラタスビル/アスナプレビル治療が著効したクリオグロブリン血管炎合併C型慢性肝疾患の一例
  • ショウレイ ホウコク ダクラタスビル/アスナプレビル チリョウ ガ チョコウシタ クリオグロブリン ケッカンエン ガッペイ Cガタ マンセイ カン シッカン ノ イチレイ

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Description

<p>A 72-year-old female was diagnosed as having chronic hepatitis C 16 years before, and her anti-viral therapies with interferon were unsuccessful. She suffered from fever, edema and purpura for two months before admission. Then, she was diagnosed with hepatitis C virus-associated mixed cryoglobulinemic vasculitis. After treatment with daclatasvir/asunaprevir, her clinical symptoms improved rapidly and she had a sustained virologic response.</p><p>Since late 2013, several novel DAAs have been approved by the FDA. Interferon-free regimens that combine such novel DAAs are highly effective for the treatment of chronic HCV infection. To our knowledge, this is the first published report documenting the efficacy of daclatasvir/asunaprevir in a patient with HCV-associated mixed cryoglobulinemic vasculitis.</p>

Journal

  • Kanzo

    Kanzo 57 (7), 328-333, 2016

    The Japan Society of Hepatology

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