Serum Bile Acid Levels in Patients with Constitutional Hyperbilirubinemias and Constitutional ICG Excretory Defect
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- NAMBU Masaji
- Department of Gastroenterology. Intemal Medicine,juntendo University, Schoal of Medicine.
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- YOSHIDA Kazuro
- Department of Gastroenterology. Intemal Medicine,juntendo University, Schoal of Medicine.
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- KOMATSU Ikutoshi
- Department of Gastroenterology. Intemal Medicine,juntendo University, Schoal of Medicine.
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- IMANARI Haruyo
- Department of Gastroenterology. Intemal Medicine,juntendo University, Schoal of Medicine.
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- OIKAWA Yoko
- Department of Gastroenterology. Intemal Medicine,juntendo University, Schoal of Medicine.
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- TAMURA Kohei
- Department of Gastroenterology. Intemal Medicine,juntendo University, Schoal of Medicine.
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- YAMASHIRO Yuji
- Department of Gastroenterology. Intemal Medicine,juntendo University, Schoal of Medicine.
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- KOBAYASHI Norio
- Department of Gastroenterology. Intemal Medicine,juntendo University, Schoal of Medicine.
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- KURODA Hiroyuki
- Department of Gastroenterology. Intemal Medicine,juntendo University, Schoal of Medicine.
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- NAMIHISA Toshihiko
- Department of Gastroenterology. Intemal Medicine,juntendo University, Schoal of Medicine.
Bibliographic Information
- Other Title
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- 体質性黄疸と体質性ICG排泄異常症における血清胆汁酸の定量分析
- タイシツセイ オウソ ト タイシツセイ ICG ハイセツ イジョウショウ ニ
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Abstract
Fasting serum bile acid levels (FSBA) were determined by the gas-liquid chromatography in six patients with constitutional hyperbilirubinemias and in two patients with constitutional indocyanine green (ICG) excretory defect.<BR>FSBA revealed within normal range (0.60±0.53μg/ml n=9) in Gilbert's (G) syndrome, DubinJohnson (D-J) syndrome and constitutional ICG excretory defect, whereas FSBA were higher (3.07-4.74μg/ml) in Crigler-Najjar (C-N) syndrome Type II and Rotor's hyperbilirubinemia (R Type).<BR>Postprandial serum bile acid levels (PSBA) were measured at two hours following having of two eggs in each one patient with G syndrome, D-J syndrome, R Type and constitutional ICG excretory defect. PSBA was significantly increased in D-J syndrome and increasing rate was 136%.<BR>There were significant correlations between serum bile acid levels and serum bilirubin concentrations, ICG plasma disappearance rate, ICG plasma retention rate, BSP plasma disappearance rate and BSP plasma retention rate.<BR>From these results it was concluded that the hepatic transport of bile acids was specifically different in constitutional hyperbilirubinemias.
Journal
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- Kanzo
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Kanzo 19 (8), 770-778, 1978
The Japan Society of Hepatology
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Keywords
Details 詳細情報について
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- CRID
- 1390001204793878656
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- NII Article ID
- 130000874506
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- NII Book ID
- AN00047770
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- COI
- 1:CAS:528:DyaE1MXitVemuw%3D%3D
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- ISSN
- 18813593
- 04514203
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- NDL BIB ID
- 1956521
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed