Serum Bile Acid Levels in Patients with Constitutional Hyperbilirubinemias and Constitutional ICG Excretory Defect

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  • NAMBU Masaji
    Department of Gastroenterology. Intemal Medicine,juntendo University, Schoal of Medicine.
  • YOSHIDA Kazuro
    Department of Gastroenterology. Intemal Medicine,juntendo University, Schoal of Medicine.
  • KOMATSU Ikutoshi
    Department of Gastroenterology. Intemal Medicine,juntendo University, Schoal of Medicine.
  • IMANARI Haruyo
    Department of Gastroenterology. Intemal Medicine,juntendo University, Schoal of Medicine.
  • OIKAWA Yoko
    Department of Gastroenterology. Intemal Medicine,juntendo University, Schoal of Medicine.
  • TAMURA Kohei
    Department of Gastroenterology. Intemal Medicine,juntendo University, Schoal of Medicine.
  • YAMASHIRO Yuji
    Department of Gastroenterology. Intemal Medicine,juntendo University, Schoal of Medicine.
  • KOBAYASHI Norio
    Department of Gastroenterology. Intemal Medicine,juntendo University, Schoal of Medicine.
  • KURODA Hiroyuki
    Department of Gastroenterology. Intemal Medicine,juntendo University, Schoal of Medicine.
  • NAMIHISA Toshihiko
    Department of Gastroenterology. Intemal Medicine,juntendo University, Schoal of Medicine.

Bibliographic Information

Other Title
  • 体質性黄疸と体質性ICG排泄異常症における血清胆汁酸の定量分析
  • タイシツセイ オウソ ト タイシツセイ ICG ハイセツ イジョウショウ ニ

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Abstract

Fasting serum bile acid levels (FSBA) were determined by the gas-liquid chromatography in six patients with constitutional hyperbilirubinemias and in two patients with constitutional indocyanine green (ICG) excretory defect.<BR>FSBA revealed within normal range (0.60±0.53μg/ml n=9) in Gilbert's (G) syndrome, DubinJohnson (D-J) syndrome and constitutional ICG excretory defect, whereas FSBA were higher (3.07-4.74μg/ml) in Crigler-Najjar (C-N) syndrome Type II and Rotor's hyperbilirubinemia (R Type).<BR>Postprandial serum bile acid levels (PSBA) were measured at two hours following having of two eggs in each one patient with G syndrome, D-J syndrome, R Type and constitutional ICG excretory defect. PSBA was significantly increased in D-J syndrome and increasing rate was 136%.<BR>There were significant correlations between serum bile acid levels and serum bilirubin concentrations, ICG plasma disappearance rate, ICG plasma retention rate, BSP plasma disappearance rate and BSP plasma retention rate.<BR>From these results it was concluded that the hepatic transport of bile acids was specifically different in constitutional hyperbilirubinemias.

Journal

  • Kanzo

    Kanzo 19 (8), 770-778, 1978

    The Japan Society of Hepatology

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