Present status of steroid administration to patients with autoimmune hepatitis and factors associated with relapse

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  • Kaneko Akira
    Department of Gastroenterology, NTT West Osaka Hospital
  • Tatsumi Tomohide
    Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine
  • Yakushijin Takayuki
    Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine
  • Hiramatsu Naoki
    Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine
  • Mita Eiji
    Department of Gastroenterology, National Hospital Organization Osaka National Hospital
  • Nakanishi Fumihiko
    Department of Gastroenterology, National Hospital Organization Osaka Minami Medical Center
  • Oshita Masahide
    Department of Gastroenterology, Osaka Police Hospital
  • Yoshihara Harumasa
    Department of Gastroenterology, Kaizuka City Hospital
  • Imai Yasuharu
    Department of Gastroenterology, Ikeda Municipal Hospital
  • Fukui Hiroyuki
    Department of Gastroenterology, Yao Municipal Hospital
  • Kobayashi Ichizo
    Department of Gastroenterology, Higashiosaka City General Hospital
  • Doi Yoshinori
    Department of Gastroenterology, Otemae Hospital
  • Hayashi Eijiro
    Department of Gastroenterology, Kenporen Osaka Central Hospital
  • Tsutsui Shusaku
    Department of Gastroenterology, Itami City Hospital
  • Shibukawa Narihiro
    Department of Gastroenterology, NTT West Osaka Hospital
  • Tatsumi Nobuyuki
    Department of Gastroenterology, NTT West Osaka Hospital
  • Hori Yumiko
    Department of Pathology, Osaka University Graduate School of Medicine
  • Morii Eiichi
    Department of Pathology, Osaka University Graduate School of Medicine
  • Takehara Tetsuo
    Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine

Bibliographic Information

Other Title
  • 自己免疫性肝炎に対するステロイド治療の現状と再燃についての検討
  • ジコ メンエキセイ カンエン ニ タイスル ステロイド チリョウ ノ ゲンジョウ ト サイネン ニ ツイテ ノ ケントウ

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Abstract

The study included 200 patients diagnosed with autoimmune hepatitis. Steroids were administered to 162 patients, and a complete response was achieved in 149 patients. However, among the 141 patients who could be evaluated, relapse was observed in 69 patients, and more than half of them relapsed at a prednisolone dose of <5 mg/day. Although there was no significant difference in factors between patients with and without relapse, we could observe significant difference in several factors when 32 patients who relapsed at a prednisolone dose of ≥5 mg/day were classified as the steroid-dependent group, and 62 patients without relapse at a maintenance dose of ≤5 mg were classified as the steroid-independent group. Multivariate analysis of these groups showed that age and cholestatic enzymes were factors associated with relapse. Our results suggest that analyzing data in consideration of steroid dose at relapse is important to investigate the factors associated with relapse.

Journal

  • Kanzo

    Kanzo 56 (10), 507-517, 2015

    The Japan Society of Hepatology

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